Working from home (WFH) is a technologically feasible solution for regular employment in many sectors and with positive impacts on health, resource consumption and the environment. This paper addresses the COVID-19 crisis as a situation where working people are forced to switch to teleworking. A global secondary perception analysis and a subsequent econometric analysis for Southern Germany at district level confirms teleworkability to be a significant tool for more climate protection if implemented in real life (WFH). Higher infection incidence seems to indicate lower levels of teleworkability or less acceptance or less responsiveness during the pandemic. Teleworkability translated into true WFH might also strengthen regional resilience against contagion.